Preheat oven to 350°. Toss together first 3 ingredients in a large bowl. Transfer mixture to a lightly greased (with cooking spray) 13- x 9-inch baking dish.

Split vanilla bean, and scrape seeds into granulated sugar. (Rub the sugar between your fingers to distribute the vanilla bean seeds evenly.)

Sift together flour, next 2 ingredients, and granulated sugar mixture into a large bowl. Stir in lemon zest. Whisk together milk, egg, and vanilla extract; stir into dry ingredients. Stir in melted butter.

Pour batter evenly over fruit; place dish on a baking sheet.

Bake at 350° for 1 hour and 5 minutes to 1 hour and 15 minutes or until crust is dark golden brown and done in center.